The Journal of Neurobehavioral Sciences

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 9  |  Issue : 2  |  Page : 51--57

The effects of flavonoids in curcumin on neurobehavioral deficits in insulin-resistant rats


Abdullahi Abiodun Mohammed1, Oluwole Busayo Akinola2 
1 Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University, Osogbo, Osun, Nigeria
2 Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Kwara, Nigeria

Correspondence Address:
Abdullahi Abiodun Mohammed
Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University, Osogbo, Osun
Nigeria

Background: Diabetes mellitus is a risk factor for dementia, particularly Alzheimer's disease (AD). In a Wistar rat model, we studied Alzheimer-like symptoms using a high-fat diet (HFD) and streptozotocin (STZ) to replicate insulin resistance and the resulting neurobehavioral abnormalities. Curcumin, a flavonoid in turmeric, was studied for its potential therapeutic effects. Aim: This study sought to look at the exploratory, discriminatory, and spatial cognitive indices in rats. Materials and Methods: Thirty-six male Wistar rats were randomized into six groups and given the following treatments: olive oil only for control; curcumin only for the curcumin group; HFD and three doses STZ for the diabetic rats; HFD, three doses STZ, and concurrent treatment with curcumin for the protective group; pretreatment with curcumin, then HFD and three doses STZ for a preventive group; and HFD, three doses STZ, and curcumin for a therapeutic group. Subsequently, line and center line crossing frequency assessed rats' exploratory activities; rearing frequency data assessed novel environment behavior. The novel object recognition test and Morris water maze test assessed discrimination and spatial memory. Data were analyzed using one-way analysis of variance and Tukey's post hoc test. P < 0.05 was considered statistically significant. Results: Our findings revealed that insulin resistance prolonged escape latency of untreated diabetic rats; contrariwise, curcumin significantly reduced escape latency, increased difference score in novel object recognition paradigm, and increased explorative activities. Conclusion: Oral curcumin improves exploratory activity, discriminating memory, and spatial memory in male Wistar rats with AD-like neurobehavioral impairments. Patients with neurobehavioral abnormalities and comorbid insulin resistance may benefit from the flavonoids in curcumin.


How to cite this article:
Mohammed AA, Akinola OB. The effects of flavonoids in curcumin on neurobehavioral deficits in insulin-resistant rats.J Neurobehav Sci 2022;9:51-57


How to cite this URL:
Mohammed AA, Akinola OB. The effects of flavonoids in curcumin on neurobehavioral deficits in insulin-resistant rats. J Neurobehav Sci [serial online] 2022 [cited 2022 Nov 30 ];9:51-57
Available from: http://www.jnbsjournal.com/article.asp?issn=2149-1909;year=2022;volume=9;issue=2;spage=51;epage=57;aulast=Mohammed;type=0