Figure 3: Micrograph of Hippocampus (CA1) of Wistar rats (H and E, × 250). (a) Control (distilled water 2 ml/kg) with normal histoarchitecture of the pyramidal cells (P). (b) Lead acetate (120 mg/kg) treated group with distortions in the histoarchitecture of the cells such as karyorrhexis (K), Ky and gliosis (g). (c) Lead acetate (120 mg/kg) and Ascorbic acid (100 mg/kg) treated group with mild distortions in the histoarchitecture of the hippocampus. Py, karyorrhexis (K), Ky, cV, and gliosis (g). (d) Lead acetate (120 mg/kg) and EECL (375 mg/kg) treated group with mild distortions in the histoarchitecture of the hippocampus. pV, Py, karyorrhexis (k), and some restoration of the histoarchitecture of the pyramidal cells (p). (e) Lead acetate (120 mg/kg) and EECL (750 mg/kg) treated group with some improvement in the histoarchitecture of the hippocampus. Karyorrhexis (k) and gliosis (g). (f) Lead acetate (120 mg/kg) and EECL (1500 mg/kg) treated group with marked improvement in the histoarchitecture of the hippocampus. Gliosis (g), karyorrhexis (K), Ky. pV: Perineuronal vacuolation, Py: Pyknosis, Ky: Karyolysis